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US 10,117,843 B2Granted
Levodopa and carbidopa intestinal gel and methods of use
AssigneeAbbVie Inc.
InventorsRajkumar Conjeevaram, Alexandru Deac, Ye Huang, Sean E. Mackey, Randy A. Menges, Jayne Zimmerman
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Abstract
The present disclosure relates to (a) an improved pharmaceutical composition comprising a levodopa active agent and a carbidopa active agent (b) methods of producing the pharmaceutical composition and (c) methods of treating Parkinson's disease and associated conditions comprising administering the pharmaceutical composition to a subject with Parkinson's disease.
Claims11
A pharmaceutical composition for intraduodenal administration comprising:
- (a) a levodopa active agent in an amount of about 4.0 weight/weight percent of the total composition;
- (b) a carbidopa monohydrate active agent in an amount of about 1.0 weight/weight percent of the total composition;
- (c) one or more polymer-based suspending agents selected from the group consisting of hydroxypropylcellulose, hydroxymethylcellulose, and sodium carboxymethyl cellulose;
- and
- (d) water,
- wherein the pharmaceutical composition has:
- (i) a high shear viscosity of no more than about 4500 cps at 22° C. and 24.1 s−1 ;
- (ii) a low shear viscosity of no less than about 45000 cps at 5° C. and 1 s−1 ;
- and
- (iii) a ratio of low shear viscosity to high shear viscosity of not less than 10.
7 more elements
Dependencies are inferred from the claim text.