Soft chew pharmaceutical formulations

A process for the manufacture of a compressed soft-chew semi-plastic unit dosage form, manufactured without molding or extrusion, for the oral administration of active pharmaceutical agents or nutritional agents comprising the steps of:

• a. forming a fluid premix comprising 5% to 20% w/w vegetable oil of the total weight of the dosage form and 5% to 20% w/w glycerin of the total weight of the dosage form;
• b. blending granulation ingredients comprising 3.0% to 25% w/w of microcrystalline cellulose, or silicified microcrystalline cellulose and at least one other excipient to form a granulation ingredient mixture;
• c. wherein at least one active pharmaceutical agent or nutritional agent is added to the fluid premix or granulation ingredient mixture;
• d. blending the fluid premix and the granulation ingredient mixture to form a soft-chew mass;
• e. a sifting the soft-chew mass to form granules of the soft-chew mass;
• f. adding a lubricant or anti-sticking agent to the granules of the soft-chew mass and compressing the resulting mixture on a tablet press to form a soft-chew semi-plastic unit dosage form, wherein the resulting dosage forms have a hardness of less than 2 kp when tested with a conventional tablet hardness tester and a friability of less than 1.0% at 100 rotations.