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US 10,117,829 B2Granted
Diclofenac formulations
AssigneeFerring B.V.
InventorsArnaud Grenier, Dario N. Carrara
Life of this patent
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Abstract
The subject invention provides improved diclofenac gel formulations.
Claims11
A transdermal or transmucosal formulation comprising:
- about 3% wt of diclofenac, about 45% wt of ethanol, about 20% wt of propylene glycol, about 5% wt of diethylene glycol monoethyl ether, and about 3% wt of myristyl alcohol.
A transdermal or transmucosal formulation comprising:
- about 3% wt of diclofenac, about 45% wt of ethanol, about 20% wt of propylene glycol, about 5% wt of diethylene glycol monoethyl ether, about 3% wt of myristyl alcohol, about 1% wt of hydroxypropyl cellulose, and water.
A method for administering diclofenac to a mammal in need thereof, the method comprising transdermally administering to the skin or a mucosal membrane of a mammal a formulation comprising:
- about 3% wt of diclofenac, about 45% wt of ethanol, about 20% wt of propylene glycol, about 5% wt of diethylene glycol monoethyl ether, and about 3% wt of myristyl alcohol.
A method for treating pain;
- post-traumatic inflammation of tendons, ligaments, muscles, and joints;
- localized forms of soft-tissue rheumatism;
- localized forms of degenerative rheumatism;
- inflammatory disorders;
- dysmenorrhea;
- actinic keratosis caused by over-exposure to sunlight;
- acute migraine;
- female breast cancer;
- pain associated with bony metastases;
- fever due to malignant lymphogranulomatosis (Hodgkin's lymphoma);
- multi drug resistant E. coli;
- Shy-Drager syndrome;
- and diabetes mellitus, said method comprising transdermally administering to the skin or a mucosal membrane of a mammal a formulation comprising:
- about 3% wt of diclofenac, about 45% wt of ethanol, about 20% wt of propylene glycol, about 5% wt of diethylene glycol monoethyl ether, and about 3% wt of myristyl alcohol.
11 more elements
A kit comprising at least one container comprising a formulation comprising:
- about 3% wt of diclofenac, about 45% wt of ethanol, about 20% wt of propylene glycol, about 5% wt of diethylene glycol monoethyl ether, and about 3% wt of myristyl alcohol and instructions for use thereof.
Dependencies are inferred from the claim text.