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US 10,117,822 B2Granted
Cross-linked hyaluronic acid, process for the preparation thereof and use thereof in the aesthetic field
AssigneeI.R.A. Istituto Ricerche Applicate S.R.L.
InventorsUgo Raffaello Citernesi, Lorenzo Beretta, Lorenzo Citernesi
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Abstract
The present invention relates, in one aspect, to the use as dermal filler of a cross-linked biopolymer compatible with the tissues of the human organism based on hyaluronic acid cross-linked with urea. The biopolymer of hyaluronic acid and urea may be applied or injected in a soft tissue of human body for tissue augmentation.
Claims10
A method for tissue augmentation of an individual, said method comprising:
- injecting under the skin of said individual, a biocompatible cross-linked biopolymer wherein said biopolymer consists of hyaluronic acid cross-linked with urea.
A method for the manufacture of a hyaluronic acid biopolymer cross-linked with urea said method comprising:
- a) dissolving hyaluronic acid or a salt thereof in a liquid to form a solution of hyaluronic acid;
- b) dissolving urea in an aqueous acidic solution with a pH of 3.5 to 4 to form an acidic aqueous solution of urea;
- c) combining the solution of hyaluronic acid with the acidic aqueous solution of urea to obtain a mixture, said mixture having a pH in the range of 3.5 to 4, wherein said hyaluronic acid biopolymer crosslinked with urea is formed as a result of said combining.
Dependencies are inferred from the claim text.