Devices and methods for treatment of ocular disorders through delivery of therapeutic nucleic acids
AssigneeDoheny Eye Institute
InventorChee Hian Tan
Life of this patent
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Abstract
Several embodiments disclosed herein relate to the delivery of therapeutic nucleic acids to an ocular tissue in order to provide a therapeutic effect to reduce symptoms of or otherwise alleviate an ocular disorder. In particular embodiments, plasmid DNA is delivered to the cells of the trabecular meshwork in order to ameliorate increasing intraocular pressure. Devices and systems to accomplish this delivery are also disclosed.
Claims23
A device for generating and applying an electrical field to an ocular target tissue, comprising:
- a first arcuate housing in which is positioned a plurality of positive electrodes;
- a second arcuate housing in which is positioned a plurality of negative electrodes,
- wherein the first arcuate housing and the second arcuate housing are configured to be coupled to form on a same plane a single ovoid-shaped structure, wherein the first and second arcuate housings are adjustable with respect to one another to adjust an outer perimeter of the single ovoid-shaped structure to a desired dimension, said desired dimension corresponding to the shape of an outer surface of an eye of a subject;
- and
- a control module configured to accept user input related to a percentage of the plurality of positive and negative electrodes to be activated on the single ovoid-shaped structure during the application of the electrical field to a specific ocular target tissue.
A device for generating and applying an electrical field to an ocular target tissue, comprising:
- a first arcuate housing in which is positioned at least one positive electrode;
- a second arcuate housing in which is positioned at least one negative electrode,
- wherein the first arcuate housing and the second arcuate housing are configured to be coupled to form on a same plane a single ovoid-shaped structure, wherein the first and second arcuate housings are adjustable with respect to one another to adjust on the same plane an outer perimeter of the single ovoid-shaped structure to a desired dimension, said desired dimension corresponding to the shape of an outer surface of an eye of a subject.
A device for generating and applying an electrical field to an ocular target tissue, comprising:
- a first arcuate housing in which is positioned at least one positive electrode;
- a second arcuate housing in which is positioned at least one negative electrode,
- wherein the first arcuate housing and the second arcuate housing are configured to be coupled to form on a same plane a single ovoid-shaped structure, wherein the first and second arcuate housings are adjustable with respect to one another to adjust on the same plane an outer perimeter of the single ovoid-shaped structure to a desired dimension, said desired dimension corresponding to the shape of an outer surface of an eye of a subject;
- and
- an injection system for delivery of a therapeutic agent to a specific ocular target tissue for the treatment of elevated intraocular pressure.
Dependencies are inferred from the claim text.