Hybrid orientation paravalvular sealing stent

A prosthetic heart valve for replacing a native valve, comprising:

• a collapsible and expandable stent having a proximal end, a distal end, and a plurality of struts defining a plurality of cells, the plurality of cells forming an aortic section, an annulus section and a subannular section of the stent, the annulus section having a first diameter in an expanded condition of the stent, the aortic section having a second diameter in the expanded condition of the stent larger than the first diameter, each of the plurality of cells in the aortic section being larger than each of the plurality of cells in the annulus section;
• and
• a valve assembly disposed within the annulus section of the stent, the valve assembly including a plurality of leaflets,
• wherein the struts of the annulus section have a first average thickness and the struts of the subannular section have a second average thickness different from the first average thickness,
• wherein the second average thickness is between about ⅓ to about 1/2 of the first average thickness.

A prosthetic heart valve for replacing a native valve, comprising:

• a collapsible and expandable stent extending in a length direction between a proximal end and a distal end, the stent including a plurality of struts defining a plurality of cells, the plurality of cells forming an aortic section, an annulus section and a subannular section of the stent;
• and
• a valve assembly disposed within the annulus section of the stent, the valve assembly including a plurality of leaflets,
• wherein the subannular section in an expanded condition of the stent has a larger diameter than the annulus section in the expanded condition of the stent,
• wherein each of the plurality of cells has a length in the length direction and a width in a circumferential direction of the stent, and for each of the plurality of cells of the subannular section the length is between about 5 mm and about 12 mm and the width is between about 9 mm and about 16 mm in the expanded condition.