Tissue ablation with irreversible electroporation

A device for ablating tissue, comprising:

• first and second electrodes configured to-position a tissue zone to be treated there between;
• a voltage generator in electrical connection with the first and second electrodes, and configured for applying a voltage between the first and second electrodes in a manner which provides a predetermined electric field around the tissue zone for a time sufficient to perform irreversible electroporation to kill substantially all of the cells in the identified tissue zone;
• and
• a voltage regulator in electrical connection with the voltage generator and configured for adjusting the voltage and pulse duration of the voltage generator to obtain irreversible electroporation of cells in the tissue zone while minimizing damage to cells not in the tissue zone, the voltage regulator is configured to use a Laplace equation to calculate the electrical potential distribution in tissue during typical electroporation pulses and is further configured to use a modified Pennes equation to calculate the resulting temperature distribution.