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US 10,117,613 B2Granted
Tissue-integrating sensors
AssigneeProfusa, Inc.
InventorsNatalie A. Wisniewski, Kristen Helton, William A. McMillan
Life of this patent
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Abstract
Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.
Claims28
A tissue-integrating sensor for detecting an analyte, consisting of:
- a hydrogel scaffold defining a plurality of hollow, interconnected pores such that capillaries can grow directly into the hydrogel scaffold;
- and
- one or more sensing moieties disposed within the hydrogel scaffold, a sensing moiety from the one or more sensing moieties configured to produce a signal in a presence of an analyte.
An apparatus, comprising:
- a hydrogel, tissue-integrating scaffold defining a plurality of hollow, interconnected pores configured such that capillaries can grow directly into the hydrogel, tissue-integrating scaffold;
- and
- a sensing moiety included within the hydrogel, tissue-integrating scaffold, the sensing moiety configured to produce a signal in a presence of an analyte.
A tissue-integrating sensor for detecting an analyte, consisting of:
- a hydrogel scaffold having a single layer defining a plurality of interconnected pores such that capillaries can grow directly into the hydrogel scaffold;
- one or more sensing moieties disposed within the hydrogel scaffold, a sensing moiety from the one or more sensing moieties configured to produce a signal in the presence of an analyte;
- and
- one or more calibration moieties disposed within the hydrogel scaffold, a calibration moiety from the one or more calibration moieties configured to produce a signal when illuminated by an excitation light.
1 more element
Dependencies are inferred from the claim text.