Methods of treating a treatment-resistant gastrointestinal spasm with an oxidized tannin

A method of treating a treatment resistant gastrointestinal spasm in a subject, the method comprising:

• administering an effective amount of a formulation to treat a gastrointestinal spasm in the subject, the formulation having a water soluble tannin combined with a hydroxyl radical to create a binding pair prior to the administering;
• wherein, the binding pair is created by a process comprising:
• selecting a water-soluble tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;
• oxidizing the tannin with a hydroxyl radical, the oxidizing including combining the tannin with the hydroxyl radical at a weight ratio ranging from about 1:1000 to about 10:1 to form the binding pair having the oxidized tannin releasably bound to the hydroxyl radical;
• wherein,
• the gastrointestinal spasm is a symptom of a condition selected from the group consisting of inflammatory bowel syndrome, Crohn's disease, ulcerative colitis, diverticulitis, colorectal cancer, stress, malnutrition, necrotic enteritis, drug side-effects, chemotherapy, radiation therapy, and gastroesophageal reflux disease;
• and,
• the formulation at least inhibits the gastrointestinal spasm when compared to a second subject in a control group in which the formulation was not administered.