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AssigneeNational Health Research Institutes
InventorsYen-Hung Chow, Yueh-Liang Tsou, Pele Choi-Sing Chong
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The present invention relates to a recombinant adenoviral vector for generating immunity against enterovirus infection. In one embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a PI protein and a 3 CD protease of an enterovirus. In another embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a 3C protease or a 3CD protease of an enterovirus. The present invention also relates to a vaccine composition comprising the recombinant adenoviral vector as described. A method of inducing an immune response in a subject against enterovirus infection using the recombinant adenoviral vector and the vaccine composition is provided. Further provided is a method for producing virus like particles of an enterovirus by expressing the adenoviral vector as described herein in mammalian cells.
A method of inducing an immune response in a subject against enterovirus infection, comprising administering to the subject an effective amount of a recombinant adenoviral vector, which comprises an expression cassette comprising the nucleic acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.