Topical brachytherapy device and method of treatment of malignant cancer

A method of manufacturing a flexible brachytherapy device for application on a wound site in a body, the method comprising:

• forming a bioresorbable carrier matrix structure comprising a plurality of radio-isotope particles, wherein the bioresorbable carrier matrix structure is configured to degrade at a rate such that the bioresorbable carrier matrix structure has a half-life that is longer than a half-life of the radio-isotope particles such that activity from the plurality of radio-isotope particles is localized to the wound site, wherein the bioresorbable carrier matrix structure has a first surface and a second surface, wherein the first surface is opposite to the second surface;
• forming a hydrophilic substrate adjacent to the first surface of the bioresorbable carrier matrix structure, wherein the hydrophilic substrate is configured to adhere to the wound site to prevent migration of the device during the half-life of the plurality of radio-isotope particles, the hydrophilic substrate configured to degrade, when implanted at the wound site, at a rate faster than the bioresorbable carrier matrix structure;
• and
• forming a hydrogel substrate adjacent to the second surface of the bioresorbable carrier matrix structure, the hydrogel substrate configured to shield radioactivity and to degrade at a rate such that the hydrogel substrate has a half-life that is longer than the half-life of the plurality of radio-isotope particles,
• wherein the radio-isotope particles are elements in compound molecules of calcium phosphate.

A multi-layered bioresorbable brachytherapy device, comprising:

• a sealed source of radiotherapy formed by hydrophobic or partially hydrophobic layers, wherein the hydrophobic or partially hydrophobic layers form a receptacle, and
• a plurality of radio-isotope particles received within the receptacle,
• wherein the receptacle is disposed between a radioactive shielding layer and a hydrophilic substrate to form the multi-layered bioresorbable brachytherapy device, the radioactive shielding layer comprising a hydrogel layer,
• wherein the hydrophobic or partially hydrophobic layers are configured to degrade, when implanted at a wound site, at a rate whereby the sealed source of radiotherapy persists for at least one half-life of the plurality of radio-isotope particles, such that activity from the plurality of radio-isotope particles is localized to the sealed source for at least one half-life of the plurality of radio-isotope particles,
• wherein the hydrogel substrate is configured to degrade, when implanted at a wound site, at a rate whereby the hydrogel substrate shields radioactivity for at least one half-life of the plurality of radio-isotope particles.