Modulation of splenocytes in cell therapy

A method for obtaining cells that have the an ability to (1) preserve splenic mass in an injury, (2) increase splenocyte proliferation in the spleen, (3) increase T-regulatory cells;

• , (4) increase one or more of IL-10 and IL-4, or (5) decrease IL-2 6and IL-1β, the method comprising:
• obtaining non-embryonic non-germ cells that express one or more of oct4, telomerase, rex-1, or rox-1 and/or can differentiate into cell types of at least two of the endodermal, ectodermal, or mesodermal germ layers;
• administering the non-embryonic non-germ cells to a subject;
• assaying the non-embryonic non-germ cells for said ability by performing one or more of:
• (1) an assay of splenic mass in an injury, (2) an assay of splenocyte proliferation in the spleen, (3) an assay of T-regulatory cells, (4) an assay of IL-10 and IL-4, and or (5) an assay of IL-2 6and IL-1β, wherein said cells that are assayed are non-embryonic non-germ cells that express one or more of oct4, telomerase rex-1 or rox-1 and/or can differentiate into cell types of at least two of the endodermal, ectodermal, and mesodermal germ layers ;
• and
• obtaining one or more non-embryonic non-germ cells that have said ability.