Process for the preparation of cis-alpha,beta substituted cyclopentanones
AssigneeFirmenich SA
InventorsDenis Jacoby, Lucia Bonomo
Life of this patent
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Abstract
Described herein is a process for the preparation of a mixture of compounds of formula having a weight ratio of the cis-diastereomers to trans-diastereoisomers higher than 1:1, where R1 represents a C1-8 alkyl group, a C2-8 alkenyl group or a C2-8 alkynyl group, each optionally substituted with one or two of a C1-4 alkyl alkoxy ether group and/or a C1-4 alkyl carboxylester group and R2 represents a C1-6 alkyl, a C2-6 alkenyl or a C2-6 alkynyl group, each optionally substituted with a C1-4 alkyl alkoxy ether group, a carboxylic acid group or a C1-4 alkyl carboxylester group and compounds suitable in the process.
Claims18
A process for the preparation of a mixture of compounds of formula
- having a weight ratio of the cis-diastereomers to trans-diastereomers higher than 1:1,
- wherein R1 represents a C1-8 alkyl group, a C2-8 alkenyl group or a C2-8 alkynyl group, each optionally substituted with one or two of a C1-4 alkyl alkoxy ether group and/or C1-4 alkyl carboxylester group, and R2 represents a C1-6 alkyl group, a C2-6 alkenyl group or a C2-6 alkynyl group, each optionally substituted with an C1-4 alkyl alkoxy ether group, a carboxylic acid group or a C1-4 alkyl carboxylester group,
- by subjecting a mixture of compounds of formula
- having a weight ratio of the cis-diastereomers to trans-diastereomers equal or lower than 1:1,
- wherein R1 and R2 have the same meaning as indicated above,
- to the steps comprising (a) ketal formation, (b) separating the trans-diastereomers and cis-diastereomers and (c) hydrolyzing the ketal of the cis-diastereomers.
Dependencies are inferred from the claim text.