Pyrimidinedione compounds

A compound having the formula:

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is a member selected from the group consisting of C1-C8 alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl-C1-C4 alkyl, 4- to 7-membered heterocycloalkyl, phenyl, phenyl-C1-C4 alkyl, 5- to 6-membered heteroaryl and 5- to 6-membered heteroaryl-C1-C4 alkyl, wherein each R1 is optionally substituted with from 1-3 Ra;
• R2 is a member selected from the group consisting of phenyl, phenyl-C1-C4 alkyl, 5- to 6-membered heteroaryl and 5- to 6-membered heteroaryl-C1-C4 alkyl, wherein each R2 is optionally substituted with from 1-5 Rb;
• R3 is a member selected from the group consisting of C1-C4 alkyl, C3-C4 cycloalkyl, and 4- to 7-membered heterocycloalkyl wherein each R3 is optionally substituted with from 1-3 Rc;
• R4 is H;
• X is a member selected from the group consisting of H and F;
• each Ra is independently selected from the group consisting of halo, CN, hydroxyl, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, phenyl, phenyl-C1-C4 alkyl, phenyl-C1-C4 alkoxy, phenoxy, —CORa1, —CO2Ra1, —SO2Ra1, —SO2NRa1Ra2, and —CONRa1Ra2, wherein each Ra1 and Ra2 is independently selected from the group consisting of H, C1-C4 alkyl and phenyl, or optionally Ra1 and Ra2 when attached to a nitrogen atom are combined to form a 4- to 6- membered ring;
• each Rb is independently selected from the group consisting of halo, CN, hydroxyl, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, phenoxy, phenyl-C1-C4 alkoxy, methylenedioxy, difluoromethylenedioxy, —CORb1, —CO2Rb1, —SO2Rb1, —SO2NRb1Rb2, CONRb1Rb2, NRb1Rb2, 5- to 6-membered heteroaryl, and 5- to 6-membered heterocyclyl optionally substituted with oxo, wherein each Rb1 and Rb2 is independently selected from the group consisting of H and C1-C4 alkyl or optionally Rb1 and Rb2 when attached to a nitrogen atom are combined to form a 4- to 6-membered ring;
• and
• each Rc is independently selected from the group consisting of halo, hydroxyl and C1-C2 alkoxy,
• wherein R1 is selected from the group consisting of C3-C4 alkyl, C3-C5 cycloalkyl, and 4- to 6-membered heterocycloalkyl, wherein each R1 is optionally substituted with from 1-2 Ra.