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US RE49,948 E1Granted
Aryl ethers and uses thereof
AssigneePeloton Therapeutics, Inc.
InventorsDarryl David Dixon, Jonas Grina, John A. Josey, James P. Rizzi, Stephen T. Schlachter, Eli M. Wallace, Bin Wang, Paul Wehn, Rui Xu, Hanbiao Yang
Life of this patent
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Abstract
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
Claims25
A compound of Formula Vd:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is aryl or heteroaryl;
- R4 is halo, cyano, alkyl, sulfonamide, sulfinyl, sulfonyl or sulfoximinyl;
- R5 is hydrogen, halo or alkyl;
- and
- R8 is hydroxy, alkylamino, alkoxy or amino.
3 more elements
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
A compound having the structure
Dependencies are inferred from the claim text.