Cytotoxic benzodiazepine derivatives
AssigneeImmunoGen, Inc.
InventorsWei Li, Michael Louis Miller, Nathan Elliott Fishkin, Ravi V. J. Chari
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Abstract
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
Claims14
A compound represented by the following structural formula:
A method for preparing compound 3b represented by the following structural formula:
- comprising reacting compound 3a represented by the following structural formula:
- with hydrogen in the presence of a palladium catalyst, to form compound 3b.
Dependencies are inferred from the claim text.