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US RE49,825 E1Granted
Piperidinyl nociceptin receptor compounds
AssigneeAstraea Therapeutics, LLC
InventorsNurulain Zaveri, Michael Meyer
Life of this patent
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Abstract
The present invention provides novel piperidinyl-containing nociceptin receptor ligand compounds and pharmaceutical compositions useful in the treatment of neurological diseases and conditions where such ligands mediate the negative effects of the condition. Such neurological diseases and conditions include acute and chronic pain, substance abuse/dependence, alcohol addiction, anxiety, depression, sleep disorders, gastrointestinal disorders, renal disorders, cardiovascular disorders and Parkinson's disease.
Claims20
A compound of structural formula (I):
- or salts, hydrates or solvates thereof wherein:
- B is hydrogen;
- R1 and R2 together with the carbon atoms to which they are attached form aryl, substituted aryl, heteroaryl or substituted heteroaryl;
- X is hydrogen, —CH═NOR4, —C(O)NR5R6, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
- Y is hydrogen, —CH═NOR7, —C(O)NR8R9, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
- R4 is hydrogen, alkyl or substituted alkyl;
- R5 is hydrogen, alkyl or substituted alkyl;
- R6 is hydrogen, alkyl, substituted alkyl or —OR15;
- R7 is hydrogen, alkyl or substituted alkyl;
- R8 and R9 are independently hydrogen, alkyl or substituted alkyl;
- and
- L is C4 cycloalkyl, C6 cycloalkyl, C7 cycloalkyl, C8 cycloalkyl, (C3-C8) substituted cycloalkyl, cyclohexyl substituted with
- (C3-C8) cycloheteroalkyl, C3 substituted cycloheteroalkyl, C5 substituted cycloheteroalkyl, C6 substituted cycloheteroalkyl, C7 substituted cycloheteroalkyl, C8 substituted cycloheteroalkyl,
10 more elements
Dependencies are inferred from the claim text.