Alkylamine derivative
AssigneeEA Pharma Co., Ltd.
InventorsMasayuki Sugiki, Toru Okamatsu, Tetsuo Yano, Shinya Taniguchi
Life of this patent
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Abstract
A composition containing a compound represented by General Formula (I) below (see the definition in the specification for the symbols in the formula) or a salt thereof has an excellent CaSR agonistic effect and provides a pharmaceutical agent, a CaSR agonistic agent, a prophylactic or therapeutic agent for a disease that can be ameliorated through CaSR activation as well as seasonings and an agent for imparting kokumi.
Claims20
A compound of Formula (I) or a salt thereof:
- wherein R1 and R2, each independently, represent a hydrogen atom, or unsubstituted C1-6 alkyl;
- R3 represents a hydrogen atom;
- R4 and R5, each independently, represent a hydrogen atom, substituted or unsubstituted C1-6 alkyl;
- X represents CH2, an oxygen atom, NH, or a sulfur atom;
- Y represents C═O, SO, SO2, or C═S;
- R6 represents a hydrogen atom;
- G represents R7-substituted phenyl or R7-substituted pyridyl, where the R7-substituted phenyl or the R7-substituted pyridyl may further be substituted with one or two R8;
- R7 represents sulfo or carboxyl;
- R8 represents substituted or unsubstituted C1-6 alkyl, halogeno, hydroxy, substituted or unsubstituted C1-6 alkoxy, sulfo, or C1-3 alkylcarbonylamino, where they may be different when more than one R8 exist;
- Q represents a hydrogen atom, substituted or unsubstituted C1-6 alkyl, carboxyl, CONReRf, CONHNHRg, CORh, phenyl, or substituted or unsubstituted oxadiazolyl;
- Re and Rf, each independently, represent a hydrogen atom, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C1-6 alkylsulfonyl, phenylsulfonyl, substituted or unsubstituted C3-8 cycloalkyl, or hydroxy, or alternatively, Re and Rf may integrally form morpholino;
- Rg represents substituted or unsubstituted C1-6 alkylcarbonyl;
- and
- Rh represents substituted or unsubstituted C1-6 alkoxy,
- provided that when X is methylene or an oxygen atom, Y is C═O, all of R1-R5 are hydrogen atoms, and G is R7-substituted phenyl optionally substituted with one or two R8, then, Q is a group other than carboxyl or CORh.
The compound represented by the following formula:
- or a salt thereof.
The compound represented by the following formula:
- or a salt thereof.
The compound represented by the following formula:
- or a salt thereof.
The compound represented by the following formula:
- or a salt thereof.
Dependencies are inferred from the claim text.