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US RE49,500 E1Granted
Pyrrole inhibitors of ERK protein kinase, synthesis thereof and intermediates thereto
AssigneeVertex Pharmaceuticals Incorporated
InventorsGabriel Martinez Botella, Michael Hale, Francois Maltais, Judith Straub, Qing Tang
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Abstract
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Claims17
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is a C1-6 aliphatic group, wherein R1 is optionally substituted with up to 2 groups independently selected from —OR or —C1-3 haloalkyl;
- each R is independently hydrogen or C1-4 aliphatic;
- R2 is R, fluoro, or chloro;
- m is 0, 1, or 2;
- and
- R3 is hydrogen, C1-3 aliphatic, fluoro, or chloro;
- wherein
- each aliphatic group is, independently, a saturated or unsaturated straight or branched hydrocarbon chain or monocyclic non-aromatic hydrocarbon.
6 more elements
A compound selected from the group consisting of:
The compound
The compound
A pharmaceutically acceptable salt of the compound
A pharmaceutically acceptable salt of the compound
Dependencies are inferred from the claim text.