RNA interference agents for GST-PI gene modulation
AssigneeNitto Denko Corporation
InventorsKenjirou Minomi, Hirokazu Takahashi, Erika Terada, Jens Harborth, Jun Zhang, Mohammad Ahmadian, Wenbin Ying
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Abstract
This invention provides compounds, compositions and methods for modulating the expression of human GST-π using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2′-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.
Claims23
A nucleic acid molecule for inhibiting expression of GST-π comprising a sense strand and an antisense strand, wherein the strands form a duplex region, and wherein the antisense strand is UAGGGUCUCAAAAGGCUUCNN SEQ ID NO:157 and the sense strand is GAAGCCUUUUGAGACCCUANN SEQ ID NO:131, wherein N is selected from the group of A, C, G, U, 2′-OMe-U, a, c, g, u, t, an inverted nucleotide, and a chemically modified nucleotide.
A nucleic acid molecule for inhibiting expression of GST-π comprising a sense strand and an antisense strand, wherein the strands form a duplex region, and wherein the antisense strand is ACAGCAGGGUCUCAAAAGGNN SEQ ID NO:195 and the sense strand is CCUUUUGAGACCCUGCUGUNN SEQ ID NO:183, wherein N is selected from the group of A, C, G, U, 2′-OMe-U, a, c, g, u, t, an inverted nucleotide, and a chemically modified nucleotide.
Dependencies are inferred from the claim text.