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AssigneesYufeng Jane Tseng, National Taiwan University, National Yang Ming Chiao Tung University, National Health Research Institutes
InventorsYufeng Jane Tseng, Yu-Li Liu, Chung-Ming Sun, Hai-Gwo Hwu, Chih-Min Liu, Wen-Sung Lai
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The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. Finding new indications for such drugs will benefit patients who are in needs for a potential new therapy sooner since known drugs are usually with acceptable safety and pharmacokinetic profiles. In this study, repurposing marketed drugs for DAAO inhibitor as new schizophrenia therapy was performed with virtual screening on marketed drugs and its metabolites. The identified and available drugs and compounds were further confirmed with in vitro DAAO enzymatic inhibitory assay.
A method of treating a disease in a subject in need thereof, comprising administering to the subject an effective amount of 5-O-desmethyl-omeprazole or a therapeutically acceptable salt, solvate, prodrug, or stereoisomer thereof, or a pharmaceutical composition containing 5-O-desmethyl-omeprazole, wherein the disease is selected from the group consisting of schizophrenia, schizoaffective disorder, mild cognitive impairment (MCI), Tourette Syndrome, ataxia, post-traumatic stress disorder (PTSD), dementia, loss of memory and/or cognition associated with neurodegenerative diseases, and loss of neuronal function characteristic of neurodegenerative diseases.
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