Ionizable cationic lipid for RNA delivery
AssigneeArcturus Therapeutics, Inc.
InventorsJoseph E. Payne, Padmanabh Chivukula
Life of this patent
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Abstract
What is described is a compound of formula (1) wherein R1 and R2 are the same or different, each a linear or branched alkyl with 1-9 carbons, or an alkenyl or alkynyl with 2 to 11 carbon atoms; L1 and L2 are the same or different, each a linear alkyl having 5 to 18 carbon atoms, or form a heterocycle with N; X1 is a bond, or is —CO—O— whereby L2-CO—O—R2 is formed; X2 is S or O; L3 is a bond or a lower alkyl, or form a heterocycle with N; R3 is a lower alkyl; and R4 and R5 are the same or different, each a lower alkyl; or a pharmaceutically acceptable salt thereof.
Claims25
A compound of formula:
- wherein:
- R1 and R2 are the same or different and each a linear or branched alkyl consisting of 1 to 9 carbons, are an alkenyl or alkynyl consisting, of 2 to 11 carbons, or cholesteryl,
- L1 and L2 are the same or different, each a linear al b lone or alkenylene consisting of 5 to 18 carbons,
- X1 is —CO—O— whereby -L2-CO—O—R2 is formed,
- X2 is S or O,
- X3 is —CO—O— whereby -L1-CO—O—R1 is formed,
- L3 is a bond,
- R3 3 is a linear or branched alkylene consisting of 1 to 6 carbons, and
- R4 and R5 are the same or different, each hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons;
- or a pharmaceutically acceptable salt thereof.
A compound of formula I
- wherein
- R1 and R2 are the same or different, each a linear or branched alkyl consisting of 1 to 9 carbons, an alkenyl or alkynyl consisting of 2 to 11 carbons, or cholesteryl,
- L1 and L2 are the same or different, each a linear alkylene or alkenylene consisting of 3 or 4 carbons,
- X1 is —CO—O— whereby -L2-CO—O—R2 is formed,
- X2 is S or O,
- X3 is —CO—O— whereby -L1-CO—O—R1 is formed,
- L3 is a bond,
- R3 is a linear or branched alkylene consisting of 1 to 6 carbons, and R4 and R5 are the same or different, each hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.