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US RE49,099 E1Granted
Humanized monoclonal antibodies against activated protein c and uses thereof
AssigneeBayer HealthCare LLC
InventorsXiao-Yan Zhao, Zhuozhi Wang, Ji-Yun Kim, Ying Zhu, Jan Tebbe
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Abstract
Provided are humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Methods of treatment employing these antibodies are described herein.
Claims19
A humanized antibody binding to activated protein C comprising:
- (a) a heavy light chain comprising heavy light chain CDRs represented by SEQ ID NOS:
- 1, 2 and 3;
- and wherein the light chain framework regions are represented by amino acid residues 1 to 23, 39 to 53, 61 to 92 and 102 to 112 of SEQ ID NO:
- 26, or having 5 or fewer conservative amino acid substitutions to SEQ ID NO:
- 26 framework regions, and
- (b) a light heavy chain comprising light heavy chain CDRs represented by SEQ ID NOS:
- 4, 5 and 6 and wherein the heavy chain framework regions are represented by amino acid residues 1 to 30, 36 to 49, 69 to 100 and 108 to 118 of SEQ ID NO:
- 16, or having 5 or fewer conservative amino acid substitutions to SEQ ID NO:
- 16 framework regions.
6 more elements
A cell or cell line comprising a nucleic acid encoding a humanized antibody binding to activated protein C comprising:
- (a) a heavy light chain comprising heavy light chain CDRs represented by SEQ ID NOS:
- 1, 2 and 3;
- and wherein the light chain framework regions are represented by amino acid residues 1 to 23, 39 to 53, 61 to 92 and 102 to 112 of SEQ ID NO:
- 26, or having 5 or fewer conservative amino acid substitutions to SEQ ID NO:
- 26 framework regions, and
- (b) a light heavy chain comprising light heavy chain CDRs represented by SEQ ID NOS:
- 4, 5 and 6, wherein the heavy chain framework regions are represented by amino acid residues 1 to 30, 36 to 49, 69 to 100 and 108 to 118 of SEQ ID NO:
- 16, or having 5 or fewer conservative amino acid substitutions to SEQ ID NO:
- 16 framework regions.
6 more elements
Dependencies are inferred from the claim text.