Embolic compositions
AssigneeBioCure, Inc.
InventorsDennis Goupil, Hassan Chaouk, Troy Holland, Bruktawit Asfaw, Stephen D. Goodrich, Lucas Latini
Life of this patent
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Abstract
Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers. When crosslinked, the macromers form hydrogels having many properties advantageous for use as embolic agents to block and fill lumens and spaces. The embolic compositions can be used as liquid embolic agents and crosslinked in situ or as preformed embolic articles, such as microspheres.
Claims26
A method for embolization, comprising the steps:
- providing a composition comprising macromers having a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups and having the formula:
- in which R is a linear or branched C1-C8 alkylene or a linear or branched C1-C12 alkane;
- R1 is hydrogen, a C1-C6 alkyl, or a cycloalkyl;
- R2 is hydrogen or a C1-C6 alkyl;
- and R3 is an olefinically unsaturated electron attracting copolymerizable radical having up to 25 carbon atoms;
- delivering the composition to the intended site of embolization, or upstream of the intended site;
- and
- then crosslinking the macromers to form a hydrogel;
- wherein the crosslinkable groups of the macromer are crosslinkable via free radical polymerization that is redox initiated;
- and the composition comprises a first solution comprising a reductant and a second solution comprising an oxidant and the macromers are present in either or both solutions.
A method of treating an animal, comprising:
- providing a composition comprising macromers having a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups and having the formula:
- in which R is a linear or branched C1-C8 alkylene or a linear or branched C1-C12 alkane;
- R1 is hydrogen, a C1-C6 alkyl, or a cycloalkyl;
- R2 is hydrogen or a C1-C6 alkyl;
- and R3 is an olefinically unsaturated electron attracting copolymerizable radical having up to 25 carbon atoms;
- delivering the composition to the animal to partially or totally block or fill a lumen, space, or cavity;
- and
- crosslinking the macromers to form a hydrogel;
- wherein the crosslinkable groups of the macromer are crosslinkable via free radical polymerization that is redox initiated;
- and
- wherein the composition comprises a first solution comprising a reductant and a second solution comprising an oxidant and the macromers are present in either or both solutions.
Dependencies are inferred from the claim text.