Methods of treating ototoxicity

A method for treating ototoxicity comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula I, II, III or IV:

• wherein
• represents a cis or trans bond;
• R1 is —C(O)ORa, —C(O)NRbRc, —C(O)H, —C(NH)NRbRc, —C(S)H, —C(S)ORa, —C(S)NRbRc, or —CN;
• R2 and R3 are each independently H or a protecting group;
• R4 and R5 are each independently H, halo, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 3-, 4-, 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S,
• Ra is a protecting group or -T1Q1;
• Rb and Rc are each independently a protecting group or -T1Q1, or Rb and Rc, together with the nitrogen atom to which they are attached, form an unsubstituted or substituted heterocycle comprising one or two 5- or 6-member rings and 1-4 additional heteroatoms selected from N, O and S;
• T1 is a bond or unsubstituted or substituted C1-C6 alkyl linker;
• and
• Q1 is H, hydroxyl, halogen, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C1-C6 alkoxy, unsubstituted or substituted 2-6 membered heteroalkyl, unsubstituted or substituted C3-C10 carbocycle, or unsubstituted or substituted heterocycle comprising one or two 3-, 4-, 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S,
• or a pharmaceutically acceptable salt, ester, solvate, or hydrate thereof,
• wherein said treating ototoxicity comprises reducing cell death or increasing cell survival of a cell from the subject suffering from ototoxicity.