# US RE47,428 E1 · Modulators of methyl modifying enzymes, compositions and uses thereof

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- Number: US RE47,428 E1
- Document ID: USRE47428E1
- Status: Granted
- Kind: E1
- Application number: 15/878,663
- Filed: 2018-01-24
- Granted: 2019-06-11
- Earliest claimed: 2013-02-11
- Assignees: Constellation Pharmaceuticals, Inc.
- Applicants: Constellation Pharmaceuticals, Inc.
- Inventors: Brian K. Albrecht; James Edmund Audia; Les A. Dakin; Victor S. Gehling; Jean-Christophe Harmange; Christopher G. Nasveschuk; Rishi G. Vaswani
- Web page: https://patentgrep.com/patent/USRE47428E1

## CPC

- A61K 31/4545: containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D 405/14: containing three or more hetero rings
- C07D 409/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 417/04: directly linked by a ring-member-to-ring-member bond
- C07D 417/14: containing three or more hetero rings
- C07D 471/04: Ortho-condensed systems
- C07D 487/04: Ortho-condensed systems
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

## Claims

### Claim 1

A compound of the formula:
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The compound of claim 1, wherein the compound is of the formula:
or a pharmaceutically acceptable salt thereof.

### Claim 3

A pharmaceutical composition comprising a compound of the formula:
or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

### Claim 4 (depends on 3)

The pharmaceutical composition of claim 3, wherein the compound is of the formula:
or a pharmaceutically acceptable salt thereof.