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US RE47,078 E1Granted
Polymorphic forms of N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide
AssigneeLaboratorio Farmaceutico C.T. S.r.l.
InventorsRoberto Cacciaglia, Massimo Ferrari
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Abstract
Crystalline polymorphic forms of a compound of formula N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide are described. The two polymorphic forms, named polymorphic Form A and polymorphic Form B, can be used in the treatment of drug addiction and alcoholism and have very good stability. Methods for preparing the polymorphic forms are also described.
Claims21
Polymorphic Form A of N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide of formula:
- having the following peaks at the diffraction degrees (2-theta) in the X-ray powder diffraction pattern ±0.2:
- 9.7;
- 12.0;
- 18.0;
- 24.1;
- 25.9, with I/I0 ratios as characterized in the following
- Peak
- 2-theta
- Intensity (cps)
- I/I0
- 1
- 6.0
- 4082
- 40
- 2
- 9.7
- 797
- 8
- 3
- 11.0
- 640
- 7
- 4
- 12.0
- 8297
- 80
- 5
- 17.6
- 2032
- 20
- 6
- 18.0
- 2173
- 21
- 7
- 18.7
- 2658
- 26
- 8
- 18.9
- 3293
- 32
- 9
- 19.6
- 919
- 9
- 10
- 20.7
- 7158
- 69
- 11
- 21.6
- 2730
- 27
- 12
- 22.2
- 2601
- 26
- 13
- 23.4
- 3261
- 32
- 14
- 24.1
- 10380
- 100
- 15
- 24.7
- 1663
- 17
- 16
- 25.9
- 5534
- 54
- 17
- 26.2
- 1771
- 18
- 18
- 28.2
- 1889
- 19.
79 more elements
Dependencies are inferred from the claim text.