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US RE46,965 E1Granted
Intermediates for the preparation of analogs of Halichondrin B
AssigneeEisai R&D Management Co., Ltd.
InventorsBrian Austad, Charles E. Chase, Francis G. Fang, Trevor Calkins, Bryan M. Lewis
Life of this patent
Estimating the term…
Abstract
The present invention provides macrocyclic compounds, synthesis of the same and intermediates thereto. Such compounds, and compositions thereof, are useful for treating or preventing proliferative disorders Formula (F-4).
Claims20
A compound of formula F-4:
- wherein:
- each of PG1, PG2, and PG3 is independently hydrogen or a suitable hydroxyl protecting group;
- R1 is R or —OR;
- each R is independently hydrogen, C1-4 haloaliphatic, benzyl, or C1-4 aliphatic;
- and
- LG1 is a suitable leaving group.
3 more elements
A compound of formula:
- and/or a pharmaceutically acceptable salt thereof.
A composition comprising a compound:
- and/or a pharmaceutically acceptable salt thereof, and
- a compound of formula:
- and/or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.