Composition and methods for the diagnosis of immune related diseases involving the PRO52254 polypeptide
AssigneeGenentech, Inc.
InventorsDaryl T. Baldwin, Sarah C. Bodary-Winter, Andrew C. Chan, Hilary Clark, Janet K. Jackman, William I. Wood
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases involving detection of the PRO52254 polypeptide.
Claims37
A method of diagnosing an immune related disease in a mammal, wherein the immune related disease is psoriasis or inflammatory bowel disease, said method comprising the steps of:
- (1) detecting the level of expression of a gene encoding the polypeptide of SEQ ID NO:2 in a test sample of tissue cells obtained from the mammal,
- (2) detecting the level of expression of the gene encoding the polypeptide of SEQ ID NO:
- 2 in a control sample of known normal tissue cells of the same cell type, and
- (3) diagnosing the immune related disease in the mammal when the level of expression of said gene in the test sample is higher as compared to the level of expression of said gene in the control sample.
A method of diagnosing an immune related disease in a mammal, wherein the immune related disease is psoriasis or inflammatory bowel disease, said method comprising the steps of:
- (a) contacting an antibody that specifically binds to a polypeptide comprising the amino acid sequence of SEQ ID NO:2, or fragments thereof, with a test sample of tissue cells obtained from said mammal,
- (b) contacting the antibody with a control sample of known normal tissue cells of the same cell type,
- (c) detecting the formation of a complex between the antibody and the polypeptide in the test sample and in the control sample, and
- (d) diagnosing the immune related disease in the mammal from which the test sample of tissue cells were obtained when the quantity of complexes formed in the test sample is larger as compared to the quantity of complexes formed in the control sample.
A method of diagnosing and treating an immune related disease in a human, wherein the immune related disease is cancer, said method comprising the steps of:
- (1) detecting the level of expression of a gene encoding the polypeptide of SEQ ID NO:
- 2 in a test sample of tissue cells obtained from the human,
- (2) detecting the level of expression of the gene encoding the polypeptide of SEQ ID NO:
- 2 in a control sample of known normal tissue cells of the same cell type,
- (3) diagnosing the immune related disease in the human when the level of expression of said gene in the test sample is higher as compared to the level of expression of said gene in the control sample, and
- (4) administering to the human a therapeutically effective amount of an antagonist of the polypeptide of SEQ ID NO:
- 2, wherein the antagonist is an antibody or antigen-binding fragment thereof.
A method of diagnosing and treating an immune related disease in a human, wherein the immune related disease is cancer, said method comprising the steps of:
- (a) contacting an antibody that specifically binds to a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, or fragments thereof, with a test sample of tissue cells obtained from said human,
- (b) contacting the antibody with a control sample of known normal tissue cells of the same cell type,
- (c) detecting the formation of a complex between the antibody and the polypeptide in the test sample and in the control sample,
- (d) diagnosing the immune related disease in the human from which the test sample of tissue cells were obtained when the quantity of complexes formed in the test sample is larger as compared to the quantity of complexes formed in the control sample, and
- (e) administering to the human a therapeutically effective amount of an antagonist of the polypeptide of SEQ ID NO:
- 2, wherein the antagonist is an antibody or antigen-binding fragment thereof.
Dependencies are inferred from the claim text.