Method for the detection of cancer
AssigneeGuardant Health, Inc.
InventorsMaurice Stroun, Philippe Anker
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method for the diagnosis and/or the follow up of the evolution of cancer, which includes the analysis and quantification of over expressed and amplified genes in the plasma/serum of cancer patients or persons suspected to harbor cancer. This is achieved by analyzing together the amount of DNA and RNA of certain genes in the plasma/serum of cancer patients that are the reflection of a gene amplification and/or a gene over expression in comparison to healthy controls.
Claims46
A method for the diagnosis or the follow up of the evolution of cancers which comprises measuring both gene over-expression (RNA) and gene amplification (DNA) of a gene present in the a sample derived from bodily fluids of fluid from a patient, that is both amplified and over-expressed in cancer cells and comparing to healthy controls, wherein the sample is cell free or substantially cell free.
A method for measuring both gene over-expression (RNA) and gene amplification (DNA) in a patient suspected of having cancer, wherein the gene measured is selected from the group consisting of hTERT, hTR, TEP1, MYCN, MYCC, ErbB2, Her2, Her2/Neu, Her 1, Cyclin A, Cyclin D1, ABL, SKP2, ETV6 (TELgene), MGC2177, PLAG1, PSMC6P and LYN, comprising:
- obtaining a sample of derived from a bodily fluid from a patient, and wherein the sample is cell free or substantially cell free, extracting both RNA and DNA simultaneously from said sample, measuring both gene over-expression (RNA) and gene amplification (DNA) at the same time in said sample from the extracted RNA and DNA, and comparing said measurement to a healthy control.
A method for the diagnosis or the follow up of the evolution of cancers which comprises measuring both the quantity of gene expression (RNA) and quantity of gene amplification (DNA) of one or more genes in a sample derived from a bodily fluid of a patient, wherein said sample is cell free or substantially cell free, and comparing to healthy controls.
Dependencies are inferred from the claim text.