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US RE43,280 E1Granted
Hyperforin derivatives, the use thereof and formulations containing them
AssigneeIndena S.p.A.
InventorsEzio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati
Life of this patent
Estimating the term…
Abstract
The use of the reduction products of hyperforin and adhyperforin, pharmaceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, in particular in the treatment of depression and Alzheimer's disease.
Claims14
A pharmaceutical composition comprising:
- hyperforin and adhyperforin derivative of formula (I)
- in which R is methyl or ethyl, R2 is hydrogen, a pharmaceutically acceptable inorganic or organic base cation or a straight or branched C2-C5 acyl residue, and in which, alternatively:
- a) R1 is 3-methyl-but-1-yl and oxo groups are present at the 1- and 10-positions;
- b) R1 is 3-methyl-2-buten-1-yl and hydroxy groups are present at the 1- and 10-positions;
- c) R1 is 3-methyl-but-1-yl and hydroxy groups are present at the 1- and 10-positions.
2 more elements
A pharmaceutical composition comprising:
- hyperforin and adhyperforin derivative of formula (I)
- in which R is methyl or ethyl, R2 is hydrogen, a pharmaceutically acceptable inorganic or organic base cation or a straight or branched C2-C5 acyl residue, and in which, alternatively:
- a) R1 is 3-methyl-but-1-yl and oxo groups are present at the 1 and 10-positions;
- b) R1 is 3-methyl-2-buten-1-yl and hydroxy groups are present at the 1- and 10-positions;
- c) R1 is 3-methyl-but-1-yl and hydroxy groups are present at the 1- and 10-positions,
- in which R2 is lithium, R1 is 3-methyl-but-1-yl and oxo groups are present at the 1- and 10-positions.
3 more elements
A compound selected from:
- dodecahydrohyperforin (Ie), dodecahydroadhyperforin (If),
- acetyloctahydrohyperforin (Ih) and
- acetyloctahydroadhyperforin (Ii).
Dependencies are inferred from the claim text.