Mammalian checkpoint proteins polypeptides and encoding sequences thereof
AssigneeBaylor College of Medicine
InventorsStephen J. Elledge, Yolanda Sanchez
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Abstract
The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The expressed proteins are used to generate specific antibodies and to inhibit the growth of cells. The human checkpoint gene sequences are used as a probe for a portion of the chromosome associated with tumors and other malignancies, as well as growth and/or development deficiencies.
Claims7
A purified human protein, wherein the protein is a polypeptide having checkpoint kinase activity and encoded by the nucleotide sequence of SEQ ID NO:
- 3.
A purified human protein comprising the amino acid sequence set forth in having checkpoint kinase activity, wherein the protein comprises SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.