Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsPaul R. Burnett, John E. van Hamont, Robert H. Reid, Jean A. Setterstrom, Thomas C. Van Cott, Deborah L. Birx
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Abstract
This invention relates to parenteral and mucosal vaccines against diseases caused by intercellular pathogens using antigens encapsulated within a biodegradable-biocompatible microspheres(matrix).
Claims14
An immunostimulating composition comprising encapsulating encapsulated microspheres comprised of (a) a biodegradable-biocompatible poly(DL-lactide-co-glycolideas poly(DL-lactide-co-glycolide) as the bulk matrix produced by a solvent evaporation process wherein the molecular weight of the copolymer is between 4,000 to 100,000 daltons and (b) an immunogenic substance consisting of a conformationally native subunit of chronic intracellular pathogen which, in the course of natural infection with that pathogen, is exposed to the host immune system on the surface of free pathogen and/or pathogen-infected cells.
Dependencies are inferred from the claim text.