# US RE39,847 E1 · Method of treating a systemic disease

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- Number: US RE39,847 E1
- Document ID: USRE39847E1
- Status: Granted
- Kind: E1
- Application number: 10/219,717
- Filed: 2002-08-15
- Granted: 2007-09-18
- Earliest claimed: 2000-08-21
- Assignees: Kos Life Sciences, Inc.
- Inventors: Akwete L. Adjei; Anthony J. Cutie
- Web page: https://patentgrep.com/patent/USRE39847E1

## Abstract

A method of treating a systemic disease in a patient in need of such treatment is disclosed. The method comprising maintaining the inspiratory flow rate and volume of the patient to a certain value and then administering a medicament aerosol formulation to such patient.

## Claims

### Claim 1

A method of treating a systemic disease in a patient in need thereof, which consists essentially of:
(a) maintaining the inspiratory flow rate in the patient in a range of about 0.05 to about 2 liters per second and the inspiratory volume of the patient in the range of about 0.1 to about 5 liters; and
(b) administering to the patient a medicinal aerosol formulation comprising
(a′) a medicament present in an effective amount; and ,
(b′) a fluid propellant carrier for carrying said transporting said medicament to the patient at a suitable dosing time of about 200 to about 2000 milliseconds for a suitable dosing period and
(c′) a stabilizer selected from the group consisting of an amino acid, a derivative thereof, a water addition stabilizer and a mixture of any of the foregoing.

### Claim 2 (depends on 1)

The method as defined in claim 1 wherein said suitable dosing time comprises about 200 to about 2000 milliseconds.

### Claim 3 (depends on 1, 2)

The method as defined in claim 1 or claim 2 wherein said suitable dosing period comprises about 1 to about 4 sprays of the aerosol formulation every 3 to 4 hours.

### Claim 4 (depends on 3)

The method as defined in claim 3 wherein said effective amount of medicament comprises from about 0.00001 parts by weight to about 5 parts by weight based on 100 parts by weight of said carrier.

### Claim 5

A method of treating a systemic disease in a patient in need thereof which comprises:
(a) administering to the patient a medicinal aerosol formulation comprising (a′) a medicament present in an effective amount; (b′) a fluid propellent carrier for carrying and transporting said medicament at a suitable dosing time for a suitable dosing period; and (c′) a stabilizer selected from the group consisting of (1) an amino acid (2) a derivative thereof; (3) a water addition stabilizer and (4) a mixture of any of the foregoing stabilizers; and
(b) maintaining the inspiratory flow rate in the patient in a range of about 0.05 to about 2 liters per second and the inspiratory volume of the patient in the range of about 0.1 to about 5 liters.

### Claim 6 (depends on 4)

The method as defined in claim 4 wherein said medicament is a particulate medicament having a diameter ranging from about 1 to about 7 micrometers.

### Claim 7 (depends on 4)

The method as defined in claim 4 wherein said medicament comprises a protein or a peptide medicament having a molecular size ranging from about 0.5 K Dalton to about 150 K Daltons.

### Claim 8 (depends on 5)

The method as defined in claim 5 wherein said stabilizer comprises said water addition stabilizer.