2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use

A compound selected from the group consisting of the formula

• wherein A is nitrogen or N→O, R1 and R2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 18 carbon atoms, R is —(CH2)mOB, Hal is halogen, m and n are individually an integer from 1 to 8, B is hydrogen or
• or —(CH2)n—Ar, Ar is mono- or polycyclic aryl or heteroaryl, Z is hydrogen or acyl of an organic carboxylic acid of up to 18 carbon atoms and its non-toxic, pharmaceutically acceptable acid addition salts.