Nude mouse model for human neoplastic disease
AssigneeAntiCancer, Inc.
InventorsAnn Monosov, Xinyu Fu
Life of this patent
Estimating the term…
Abstract
A nude mouse model for human neoplastic diseases having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the tissue is obtained.
Claims50
A nude mouse model for progression of human neoplastic disease, the progression of said disease being characterized by growth of a primary tumor site and metastasis to secondary tumor sites, wherein said mouse is characterized by
- having has histologically intact human neoplastic tissue of at least 1 mm3 in size transplanted onto an organ of said mouse which corresponds to the human organ from which said tissue is originally obtained;
- and
- having has sufficient immuno-deficiency to allow said transplanted neoplastic tissue to grow and at said primary site and metastasize to said secondary tumor sites, so as to mimic the progression of the neoplastic disease including the metastatic behavior of said neoplastic disease in the human donor humans.
A method of generating a nude mouse model for progression of human neoplastic disease, the progression of said disease being characterized by growth of a primary tumor site and metastasis to secondary tumor sites, said method comprising:
- transplanting histologically intact human neoplastic tissue of at least 1 mm3 in size transplanted onto an organ of a nude mouse which corresponds to the human organ from which said tissue is originally obtained;
- and
- allowing said transplanted tissue to grow and at said primary site and metastasize to said secondary tumor sites, so as to mimic progression of the neoplastic disease including the metastatic behavior of said neoplastic disease in the human donor humans.
A nude rodent model for progression of human neoplastic disease, the progression of said disease being characterized by growth of a primary tumor site and metastasis to secondary tumor sites, wherein said rodent has histologically intact human neoplastic tissue of at least 1 mm3 in size transplanted onto an organ of said rodent which corresponds to the human organ from which said tissue is originally obtained;
- and
- has sufficient immuno-deficiency to allow said transplanted neoplastic tissue to grow at said primary site and metastasize to said secondary tumor sites, so as to mimic the progression of the neoplastic disease including the metastatic behavior of said neoplastic disease in humans.
An immunodeficient rodent model for progression of human neoplastic disease, the progression of said disease being characterized by growth of a primary tumor site and metastasis to secondary tumor sites, wherein said rodent has histologically intact human neoplastic tissue of at least 1 mm3 in size transplanted onto an organ of said rodent which corresponds to the human organ from which said tissue is originally obtained;
- and
- has sufficient immuno-deficiency to allow said transplanted neoplastic tissue to grow at said primary site and metastasize to said secondary tumor sites, so as to mimic the progression of the neoplastic disease including the metastatic behavior of said neoplastic disease in humans.
A method of generating a nude rodent model for progression of human neoplastic disease, the progression of said disease being characterized by growth of a primary tumor site and metastasis to a secondary tumor sites, said method comprising:
- transplanting histologically intact human neoplastic tissue of at least 1 mm3 in size onto an organ of a nude rodent which corresponds to the human organ from which said tissue is originally obtained;
- and
- allowing said transplanted tissue to grow at said primary site and metastasize to said secondary tumor sites, so as to mimic progression of the neoplastic disease including the metastatic behavior of said neoplastic disease in humans.
A method of generating an immunodeficient rodent model for progression of human neoplastic disease, the progression of said disease being characterized by growth of a primary tumor site and metastasis to secondary tumor sites, said method comprising:
- transplanting histologically intact human neoplastic tissue of at least 1 mm3 in size onto an organ of an immunodeficient rodent which corresponds to the human organ from which said tissue is originally obtained;
- and
- allowing said transplanted tissue to grow at said primary site and metastasize to said secondary tumor sites, so as to mimic progression of the neoplastic disease including the metastatic behavior of said neoplastic disease in humans.
A nude rodent model for progression of human neoplastic disease, the progression of said disease being characterized by growth of a primary tumor site and metastasis to secondary tumor sites, wherein said rodent has histologically intact human neoplastic tissue transplanted onto an organ of said rodent which corresponds to the human organ from which said tissue is originally obtained;
- and
- has sufficient immuno-deficiency to allow said transplanted neoplastic tissue to grow at said primary site and metastasize to said secondary tumor sites, so as to mimic the progression of the neoplastic disease including the metastatic behavior of said neoplastic disease in humans.
An immunodeficient rodent model for progression of human neoplastic disease, the progression of said disease being characterized by growth of a primary tumor site and metastasis to secondary tumor sites, wherein said rodent has histologically intact human neoplastic tissue transplanted onto an organ of said rodent which corresponds to the human organ from which said tissue is originally obtained;
- and
- has sufficient immuno-deficiency to allow said transplanted neoplastic tissue to grow at said primary site and metastasize to said secondary tumor sites, so as to mimic the progression of the neoplastic disease including the metastatic behavior of said neoplastic disease in humans.
Dependencies are inferred from the claim text.