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US RE39,324 E1Granted
Pyrimidine derivatives and oligonucleotides containing same
AssigneeIsis Pharmaceuticals, Inc.
InventorsKuei-Ying Lin, Mark D. Matteucci
Life of this patent
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Abstract
Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compounds as labels in diagnostic assays and to enhance binding to complementary bases.
Claims30
A compound having the structure (1):
- and tautomers, solvates and salts thereof, wherein
- R1 is an oligonucleotide, a protecting group, a linker or —H;
- R2 is A(Z)X1, wherein A is a spacer and Z independently is a label bonding group optionally bonded to a detectable label, but R2 is not amine NH2, protected amine NH2, nitro or cyano;
- R27 is independently —CH═, —N═, —C(C1-C8 alkyl)═ or —C(halogen)═, but no adjacent R27 are both —N═, or two adjacent R27 are taken together to form a ring having the structure,
- wherein Ra is independently —CH═, —N═, —C(C1-8alkyl)═ or —C(halogen)═, but no adjacent Ra are both —N═;
- R34 is —O—, —S— or —N(CH3)—;
- and
- X1 is 1, 2 or 3.
5 more elements
Dependencies are inferred from the claim text.