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US RE38,117 E1Granted
Trioxane dimer compound having antiproliferative and antitumor activities
AssigneesHauser, Inc., Johns Hopkins
InventorsQun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh, Poonsakdi Ploypradith, Gary H. Posner
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Abstract
Described herein are novel trioxane dimers of structure which possess antiproliferative and antitumor activities.
Claims23
A trioxane dimer compound having antiproliferative and antitumor activities of the formula:
- or an enantiomers enantiomer thereof, wherein:
- R1 is CH3, PhCH2Cl PhCH(Cl), (PhCH2—) or PhCl2;
- and
- R is a linker when T is CH2O;
- or
- R is oxygen when T is CH2.
3 more elements
A trioxane dimer compound having antiproliferative and antitumor activities of the formula:
- or an enantiomer thereof, wherein:
- R is arylene, hetero-arylene, lower alkylene, lower alkenylene, a bivalent phosphate species, sulfur oxygen —(CH2CH2O)n— wherein n is 1-20 or —CH2CH2— (XCH2CH2)n— where X is O, S or NY where Y is H (hydrogen) or alkyl and n is 1-20, or R is —W—Z—W— where W is a bivalent ester, carbonate or carbonate species and Z is arylene, polyethylene glycol (PEG), hetero-arylene, lower alkylene, or lower alkenylene.
A trioxane dimer compound having antiproliferative and antitumor activities of the formula:
- or an enantiomer thereof, wherein:
- R1 is H, CH3, PhCH2Cl or PhCl2;
- and
- R is a linker other than
- and T is CH2O;
- or
- R is oxygen when T is CH2.
4 more elements
A trioxane dimer compound having antiproliferative and antitumor activities of the formula:
- or an enantiomer thereof, wherein:
- R1 is H, CH3, PhCH(Cl), PhCH2, PhCl2;
- and
- T is CH2O when R is a linker other than
- or
- R is oxygen when T is CH2.
3 more elements
Dependencies are inferred from the claim text.