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US RE38,081 E1Granted
Method of hemodilution facilitated by monitoring oxygenation status
OwnerNicholas Simon Faithfull, Peter E. Keipert +2inventors
InventorsNicholas Simon Faithfull, Peter E. Keipert, Duane J. Roth, Ronald M. Hopkins
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Abstract
A method for hemodiluting a patient is disclosed which includes the steps of administering a biocompatible oxygen carrier in conjunction with surgery or organ ischemia or infarct while assessing the patient's PvO2 or other oxygenation indices, and administering to the patient additional oxygen carrier or autologous blood in response to the PvO2 value if necessary to maintain the PvO2 at or above the desired level.
Claims26
A method of hemodiluting a patient, comprising the steps of:
- removing and storing a portion of the patient's blood while intravenously and administering a biocompatible oxygen carrier, after which the patient undergoes a further loss of blood wherein the removal and further loss of blood reduces the patient's hematocrit value hemoglobin concentration to about 8 g/dL or below;
- monitoring the patient's tissue oxygenation status during said removal and further loss of blood, whereby the patient's hematocrit value hemoglobin concentration is maintained at a level of about 8 g/dL or below;
- and
- administering additional biocompatible oxygen carrier to the patient during or after said further loss of blood in response to said oxygenation status to maintain said oxygenation status at or above a desired value.
1 more element
A method of hemodiluting a patient, comprising the steps of:
- removing and storing a portion of the patient's blood while intravenously and administering a biocompatible oxygen carrier;
- simultaneously monitoring the patient's tissue oxygenation status, wherein biocompatible oxygen carrier is administered so that said tissue oxygenation status is maintained at or above a desired value;
- stopping removal of the patient's blood when the hemoglobin concentration in the patient reaches a point corresponding to a hematocrit value of about 8 g/dL or below;
- continuing to monitor the patient's tissue oxygenation status while allowing the patient to undergo a further loss of blood, whereby the patient's hematocrit value hemoglobin concentration is maintained at a level of about 8 g/dL or below;
- and
- intravenously readministering blood removed during said removing step in an amount sufficient to maintain said oxygenation level at or above a desired value and concomitantly increasing said hematocrit value hemoglobin concentration above 8 dg/L.
3 more elements
Dependencies are inferred from the claim text.