Nitrosated and nitrosylated compounds, and compositions and their use for treating respiratory disorders

A compound having the structure:

• wherein
• A is selected from —CH═CH— or —CH2—CH2—;
• R1 is selected from hydrogen or —C(O)CH2—B—D, wherein B is oxygen or sulfur and D is selected from (i) hydrogen, (ii) —NO and (iii) or —NO2;
• with the provision that when B is oxygen then D is H or —NO ;
• R2 and R3 are independently selected from hydrogen, hydroxyl, lower alkyl, —O(O)C—Ri, or —S—Ri wherein Ri is hydrogen, lower alkyl or lower haloalkyl, or when taken together are:
• wherein Ri1 and Ri2 are independently selected from Ri wherein Ri is defined as above;
• R4 and R5 are independently selected from hydrogen or halogen;
• R6 is selected from hydrogen, —NO, —NO2 and —C(O)CH2—B—D, wherein B is oxygen or sulfur and D is selected from hydrogen, —NO and —NO2, with the provision when R1 is hydrogen, or the D group of R1 is hydrogen or —NO, with the B group being oxygen then R6 is selected from the group consisting of —NO, NO2 and —C(O)CH2—B—D, wherein B is oxygen or sulfur and D is —NO or —NO2;
• or an ester or thioester of said compound .