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AssigneeBristol-Myers Squibb Company
InventorsMichael C. Tao, Richard E. Litov, John R. Euber, Salim S. Akrabawi, J. Roberto Moran
Estimating the term…
An improved oral rehydration solution comprising a mixture of rice dextrin and required electrolytes is provided. The functionality of the rice dextrin in oral rehydration solutions is superior to glucose in infants with chronic diarrhea , resulting in lower stool output and enhanced water retention during the initial six hours of therapy . Rice dextrin also has a polymer profile which provides more readily available glucose than corn dextrin or rice flour. There is also provided a process for clarifying solutions of rice dextrin which involves a first filtration at 35.degree. C. and 50.degree. C. and a second filtration at temperatures above 80.degree. C. using filter aid and activated carbon.
An improved oral rehydration solution containing electrolytes and carbohydrate wherein the improvement comprises using rice dextrin as the carbohydrate component, said rice dextrin having a glucose polymer profile of from 50 to 90% short chain glucose polymers of 2 to 6 glucose ..unit.!. units , and having a protein or other particulate content of no more than one tenth of one percent.
A process for clarifying rice dextrin comprising the steps of
A method for treating diarrhea which comprises administering to a patient in need of such treatment an oral rehydration solution containing electrolytes and carbohydrate wherein said carbohydrate is rice dextrin having a glucose polymer profile of from 50 to 90% short chain glucose polymer of 2 to 6 glucose units, and having a protein or other particulate content of no more than one tenth of one percent.
An oral rehydration solution containing electrolytes and carbohydrates, wherein said carbohydrate material comprises rice dextrin short chain glucose polymers of 2 to 6 glucose units.
A method for treating diarrhea which comprises administering to a patient in need of such treatment an oral rehydration solution containing electrolytes and carbohydrates, wherein said carbohydrate comprises rice dextrin short chain glucose polymers of 2 to 6 glucose units.
A method of treating dehydration which comprises administering to a patient in need of such treatment an oral rehydration solution containing electrolytes and carbohydrates, wherein said carbohydrate material comprises rice dextrin short chain glucose polymers of 2 to 6 glucose units.
A method for preventing dehydration which comprises administering to a patient in need of such treatment an oral rehydration solution containing electrolytes and carbohydrates, wherein said carbohydrate material comprises rice dextrin short chain glucose polymers of 2 to 6 glucose units.
A method for maintenance of hydration which comprises administering to a patient in need of such treatment an oral rehydration solution containing electrolytes and carbohydrates, wherein said carbohydrate material comprises rice dextrin short chain glucose polymers of 2 to 6 glucose units.
The clarified rice dextrin material comprising a glucose polymer of 2 to 6 glucose units which, when in the form of a liquid composition, comprises a protein or other particulate content of no
A process for clarifying rice dextrin, which clarified rice dextrin is useful for preparing an oral rehydration solution, comprising the step of filtering an aqueous admixture comprising solubilized rice dextrin until the protein content of said rice dextrin is reduced to no more than one tenth of one percent said filtering step being carried out at elevated temperatures.
Dependencies are inferred from the claim text.