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US RE35,609 EGranted
Process for purifying 2',3'-dideoxynucleosides
AssigneeAjinomoto Co., Inc.
InventorsMasaru Otani, Toshiya Tanabe
Life of this patent
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Abstract
A biological process for producing a 2',3'-dideoxynucleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin absorbent.
Claims16
A process for the purification of a 2',3'-dideoxynucleoside from a solution obtained from a process requiring a microorganism or an enzyme, said solution containing, as impurities, other 2',3'-dideoxynucleosides or nucleic acid bases, said process comprising:
- (i) contacting said solution with a porous, nonpolar resin to cause the adsorption of said 2',3'-dideoxynucleoside onto said porous nonpolar resin, wherein said 2',3'-dideoxynucleoside is 2',3'-dideoxyadenosine or 2',3'-dideoxyinosine;
- (ii) separating said porous nonpolar resin from said solution;
- and
- (iii) fractionally eluting said adsorbed 2',3'-dideoxynucleoside to obtain a purified 2',3'-dideoxynucleoside product.
1 more element
Dependencies are inferred from the claim text.