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US RE35,152 EGranted
Method for the diagnosis and treatment of inflammation
AssigneeThe General Hospital Corporation
InventorsRobert H. Rubin, H. William Strauss
Life of this patent
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Abstract
The invention relates to a method of detecting an inflammation site in an individual by administering to the individual a diagnostically effective amount of detectably labeled immunoglobulin or fragment thereof, wherein the immunoglobulin substantially accumulates at the site when the site is inflamed.
Claims34
A method of detecting an inflammation site in vivo in an individual which comprises:
- (a) administering to said individual a diagnostically effective amount of [a] an agent wherein said agent [consists essentially of] comprises a detachably labeled immunoglobulin or [a] an Fc fragment or subfragment thereof, and said immunoglobulin , or Fc fragment or subfragment thereof, substantially accumulates at said site when said site is inflamed and said agent has no substantial epitopic specificity for said inflamed site[,] ;
- and
- (b) detecting said [detectably labeled immunoglobulin] agent .
A method of detecting the underlying cause of an inflammatory response in vivo in an individual which comprises:
- (a) administering to said individual a diagnostically effective amount of a first agent, wherein said first agent comprises a detectably labeled , non-specific immunoglobulin or [a] an Fc fragment or subfragment thereof, and wherein said immunoglobulin or Fc fragment or subfragment substantially accumulates at said site when said site is inflamed;
- (b) imaging said individual to detect the presence of a site of inflammation;
- (c) based on the presence of a site of inflammation as demonstrated by step (b), further administering to said individual a diagnostically effective amount of a detectably labeled specific antibody or a fragment thereof, wherein said detectably labeled specific antibody or fragment thereof can specifically bind to the underlying cause of the inflammatory response;
- and
- (d) imaging said individual to detect the presence of the detectable labeled specific antibody or fragment thereof bound to the underlying cause of the inflammation at the site of the inflammation.
2 more elements
A method of detecting an inflammation site in vivo in an individual which comprises:
- (a) administering to said individual a diagnostically effective amount of an agent wherein said agent comprises a detachably labeled immunoglobulin or an Fc fragment or subfragment thereof, and said immunoglobulin, or Fc fragment or subfragment thereof, substantially accumulates at said site when said site is inflamed wherein said accumulation is substantially independent of the epitopic specificity of the immunoglobulin;
- and
- (b) detecting said agent.
Dependencies are inferred from the claim text.