Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency
AssigneeThe Research Foundation of State University of New York
InventorsLorne M. Golub, Thomas F. McNamara, Nungavaram S. Ramamurthy
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Abstract
Tetracyclines, antibacterial and non-antibacterial tetracyclines, have been found to be useful in the treatment of osteoporosis in humans by administering to the human suffering from osteoporosis an effective amount of a tetracycline to enhance bone protein synthesis. Tetracyclines which have been found to be effective in the treatment of osteoporosis in humans include minocycline, doxycycline and dedimethylaminotetracyline.
Claims20
[A] The method of [enhancing bone protein synthesis in a human which comprises administering to the human an effective amount of a tetracycline] claim 20 wherein said disease is osteoporosis .
A method in accordance with claim [1] 20 wherein said tetracycline is an antibacterial tetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is non-antibacterial tetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is minocycline.
A method in accordance with claim [1] 20 wherein said tetracycline is doxycycline.
A method in accordance with claim [1] 20 wherein said tetracycline is 7-chlorotetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is 5-hydroxytetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is 6-demethyl-7-chlorotetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is 6-demethyl-6-deoxy-5-bydroxy-6-methylenetetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is dedimethylamimotetracycline.
A method in accoredance with claim [1] 20 wherein said tetracycline is 6-alpha-benzylthiomethylenetetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is a nitrile analog of tetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is a mono-N-alkylated amide of tetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is 6-fluorodemethyltetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is 11-alpha-chlorotetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is 2-acetyl-8-hydroxyl-1-tetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is 6-demethyl-6-deoxytetracycline.
A method in accordance with claim [1] 20 wherein said tetracycline is administered systemically.
A method in accordance with claim [1] 20 wherein said tetracycline is administered orally.
A method of treating mammal with bone deficiency disease by enhancing bone protein synthesis in said mammal which comprises administering to the mammal an effective amount of a tetracycline.
Dependencies are inferred from the claim text.