Vitaminized compositions for treating hypercholesterolemia
AssigneeThe Procter & Gamble Company
InventorsRonald J. Jandacek, Fred H. Mattson, Harry M. Taylor
Life of this patent
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Abstract
Anti-anal leakage agents are used in combination with vitamin-fortified liquid fatty acid polyester compositions to provide pharmaceutical and food compositions for treating and/or preventing hypercholesterolemia while avoiding undesired anal leakage of the polyesters.
Claims69
A composition of matter, comprising
- a. an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms:
- b. sufficient anti-anal leakage agent , other than tristearin, to prevent leakage of said liquid polyester through the anal sphincter;
- and
- c. said composition being fortified with sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K , over and above that naturally present in said composition, to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
A method for inhibiting the absorption of cholesterol without decreasing the body's stores of fat-soluble vitamins or causing an anal leakage effect comprising systemically administering to an animal susceptible to or afflicted with hypercholesterolemia successive therapeutically effective doses of a composition comprising a non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms;
- sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter;
- and sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, and mixtures thereof, to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
A low calorie fat-containing food composition comprising non-fat ingredients and fat ingredients, wherein from about 10% to about 100% of the total fat ingredients comprise:
- a. a portion comprising an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms;
- and
- b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter.
- said food composition being fortified with sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, or mixtures thereof, over and above that naturally present in said food composition, to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
A pharmaceutical composition in effective unit dosage amounts for inhibiting the absorption of cholesterol without causing an anal leakage effect or interfering with the body's stores of fat-soluble vitamins, comprising:
- a. from about 0.1 gram to about 5 grams of an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms;
- b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter;
- and
- c. sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
Dependencies are inferred from the claim text.