Indolo isoquinoline compounds
AssigneeLilly Industries Limited
InventorsDavid C. Horwell, David E. Tupper
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Abstract
Isoquinoline compounds of the following formula are described: ##STR1## wherein the moiety A-B represents a group of formula: --CH.sub.2 --NR.sup.3 -- or --NR.sup.3 --CH.sub.2 --; wherein R.sup.3 represents hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl, optionally substituted benzyl, C.sub.3-6 alkenyl or C.sub.1-4 alkanoyl; wherein R represents hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, or optionally substituted benzyl; wherein R.sup.1 and R.sup.2 each represent hydrogen or taken together represent a chemical bond; and wherein X is hydrogen or halogen; or an acid-addition salt thereof. The compounds are pharmaceuticals and especially useful in the treatment of disorders of the central nervous system.
Claims1
A compound of the formula:
- ##STR11## where the moiety D-E represents a group of the formula:
- ##STR12## wherein R.sup.3 represents hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl, benzyl, benzyl substituted with from 1-3 of the following substituents:
- halogen, methyl, methoxy, nitro;
- C.sub.3-6 alkenyl or C.sub.1-4 alkanoyl;
- wherein R represents hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, benzyl, benzyl substituted with from 1-3 of the following substituents:
- halogen, methyl, methoxy, nitro;
- and
- wherein R.sup.1 and R.sup.2 when D- E is ##STR13## each represent hydrogen and when D-E is ##STR14## represent hydrogen when taken singly, or taken together represent a chemical bond.
Dependencies are inferred from the claim text.