Substituted pyrroloquinoxalinones and diones
AssigneeEli Lilly and Company
InventorRichard E. Holmes
Life of this patent
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Abstract
Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.
Claims4
[1. A method of treating vascular thrombosis according to the method of claim 2 in mammals which comprises administering to a mammal in need of such treatment an amount of 6-phenyl-1H-pyrrolo-[1,2,3-de]quinoxalin-2,5[3H,6H]-dione effective for treating vascular thrombosis.]
[2. A method of treating vascular thrombosis in mammals which comprises administering to a mammal in need of such treatment an amount of a compound of the formula effective for treating vascular thrombosis.] ##STR5## [wherein
- R.sup.1 is H or C.sub.1 -C.sub.3 alkyl;
- when taken singly,
- R.sup.2 is H, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, or Cl and R.sup.3 is H;
- and
- R.sup.2 and R.sup.3 when taken together with the carbon atoms to which they are attached form a benzene ring;
- R.sup.4 is H, Cl or F;
- R.sup.5 is OH, H or phenyl;
- Y is O or H.sub.2 ;
- Z is --CH.sub.2 --CH.sub.2 -- or --CHR.sup.6 -- wherein R.sup.6 is H or
- C.sub.1 -C.sub.3 alkyl.]
A method of treating vascular thrombosis in mammals which comprises administering to a mammal in need of such treatment an amount of a compound of the formula effective for treating vascular thrombosis. ##STR6## wherein R.sup.1 is H or C.sub.1 -C.sub.3 alkyl;
- when taken singly,
- R.sup.2 is H, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, F or Cl and R.sup.3 is H;
- and
- R.sub.2 and R.sup.3 when taken together with the carbon atoms to which they are attached form a benzene ring;
- R.sup.4 is H, Cl or F;
- R.sup.5 is OH, H or phenyl;
- Y is O or H.sub.2 ;
- Z is --CH.sub.2 --CH.sub.2 -- or --CHR.sup.6 -- wherein R.sup.6 is H or
- C.sub.1 -C.sub.3 alkyl.
Dependencies are inferred from the claim text.