Crystalline p-hydroxyampicillin and salts thereof
AssigneeBeecham Group Limited
InventorsAnthony Alfred Walter Long, John Herbert Charles Nayler
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Abstract
Derivatives of 6-Aminopenicillanic Acid possessing antibacterial activity are disclosed.
Claims9
[1. A compound selected from the group consisting of 6-[(-)-.alpha.-amino-p-hydroxyphenylacetamido]-penicillanic acid and the non-toxic, pharmaceutically acceptable acid addition and base addition salts thereof and salts with non-toxic amines.]
[2. A compound or salt according to claim 1 which is amorphous or crystalline in form.]
[3. A compound or salt according to claim 1 which is anhydrous or hydrated.]
[4. A compound or salt according to claim 1 which is free of traces of high molecular weight allergenic impurities.]
[5. A compound or salt according to claim 1, wherein the salt is selected from the group consisting of the hydrochloric, phosphoric, sulfuric, thiocyanic and .beta.-naphthalene sulfonic acids and the sodium and potassium alkali metal salts.]
Crystalline 6-(-)-.alpha.-amino-p-hydroxyphenylacetamido]-penicillanic acid trihydrate.
Crystalline 6-[(-)-.alpha.-amino-p-hydroxyphenylacetamido] penicillanic acid hydrochloride trihydrate.
Crystalline di-(6-[(-)-.alpha.-amino-p-hydroxyphenylacetamido] penicillanic acid) sulphate.
Crystalline 6-[(-)-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido] penicillanic acid .beta.-naphthalenesulphonate trihydrate.
Dependencies are inferred from the claim text.