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US H2,153 H1Granted
Association of asthma with polymorphisms in the cysteinyl leukotriene 2 receptor
AssigneeSmithKline Beecham Corporation
InventorsDiane Michele Ignar, Sreekumar Pillai
Life of this patent
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Abstract
Polymorphisms in the cysteinyl-leukotriene receptor 2 gene and their association with asthma are described.
Claims3
A method of identifying a subject at increased risk of asthma, comprising detecting the allelic forms of the A601G polymorphism in the Cysteinyl leukotriene 2 receptor gene, where a person homozygous for the A allele is at increased risk for asthma compared to a subject with at least one G allele.
A method of stratifying a population receiving pharmaceutical treatment for asthma to detect differences in phenotypic response to the pharmaceutical treatment, by:
- (a) genotyping a population of subjects in need of pharmaceutical treatment for asthma, to determine each subject's allelic forms of the A601G polymorphism in the Cysteinyl leukotrine 2 receptor gene;
- (b) administering to said subjects a pharmaceutical treatment for asthma;
- (c) correlating each subject's phenotypic response to treatment with the subject's genotype, to detect phenotypic responses that are associated with said allelic forms.
Dependencies are inferred from the claim text.