Streptococcus pneumoniae gene sequence for DNA ligase
AssigneeEli Lilly and Company
InventorsJo Ann Hoskins, Stanley Richard Jaskunas, Jr., Timothy Ivan Meier, Pamela Kay Rockey, Genshi Zhao
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Abstract
The invention provides isolated nucleic acid compounds encoding a DNA ligase of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
Claims22
An isolated nucleic acid fragment, wherein said fragment has a sequence selected from the group consisting of:
- (a) SEQ ID NO:
- 1;
- (b) SEQ ID NO:
- 3;
- (c) a nucleic acid fragment that encodes the same protein as depicted in SEQ ID NO:2;
- and
- (d) a nucleic acid fragment fully complementary to (a), (b), or (c).
An isolated nucleic acid fragment encoding a protein having the amino acid sequence that is SEQ ID NO:2.
An isolated nucleic acid fragment, wherein said fragment consists essentially of a sequence selected from the group consisting of:
- (a) SEQ ID NO:
- 1;
- (b) SEQ ID NO:
- 3;
- (c) a nucleic acid fragment that encodes the same protein as depicted in SEQ ID NO:2;
- and
- (d) a nucleic acid fragment fully complementary to (a), (b), or (c).
An isolated nucleic acid fragment consisting essentially of a nucleotide sequence encoding a protein having the amino acid sequence that is SEQ ID NO:2.
Dependencies are inferred from the claim text.